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KMID : 1204320090250010041
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Laboratory Animal Research
2009 Volume.25 No. 1 p.41 ~ p.46
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Overexpression of c-Fos in the Dysplastic Bile Ducts and Cholangiocarcinoma and Its Association with Cell Proliferating Activity in the Hamster Cholangiocarcinoma Model
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Yoon Byung-Il
Kim Yong-Baek
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Abstract
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The oncogene c-Fos involved in cell cycle progression is rapidly and transiently induced by a variety of agents and functions as a transcriptional regulator for several genes such as activator protein-1 (AP-1). In various cancers including squamous cell carcinoma, hepatocellular carcinoma and osteosarcoma, c-Fos expression may be relevant to the carcinogenic events. In the present study, the expression patterns and the potential importance of c-Fos in cholangiocarcinogenesis were evaluated by immunohistochemical staining for c-Fos in the selected each five cases of precancerous lesion (interim stage of cholangiocarcinogenesis, 8 weeks after liver fluke infection) and cholangiocarcinoma (ChC) derived from the hamster ChC model. Additionally, c-Fos immunoreactivity of 5 cases of carcinogen-unaffected hyperplastic bile ducts obtained from 12-day bile duct ligation model was also evaluated. Nuclear expression of c-Fos was apparent in most of the cell components of dysplastic bile ducts and cholangiocarcinoma. However, normal and well-organized hyperplastic bile ducts (type 1 hyperplastic bile ducts) were almost negative. These expression patterns were positively correlated with those of proliferating cell nuclear antigen (PCNA), suggesting that c-Fos overexpression might be associated with the high cellular proliferating activity and cell transformation in the hamster cholangiocarcinogenesis.
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KEYWORD
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cell proliferation, cholangiocarcinoma, c-Fos, hamster, immunohistochemistry
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