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KMID : 1204320090250010065
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Laboratory Animal Research
2009 Volume.25 No. 1 p.65 ~ p.67
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A Spontaneous Uterine Leiomyosarcoma in an Aged Mongolian Gerbil (Meriones unguiculatus)
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Hong Sun-Hwa
Lee Hyun-A
Song Jae-Ho
Kim Ok-Jin
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Abstract
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A spontaneous uterine leiomyosarcoma was observed in a 2-year-old female Mongolian gerbil (Meriones unguiculatus). Postmortem examination revealed that the left horn of the uterus was enlarged and nodular shaped. The masses were white, smooth, and glistened at the cut surfaces. Histologically, the pedunculated masses were continuous with the myometrium, which were composed of closely packed sheets of spindle cells embedded in richly vascularized stroma and covered by a discontinuous endometrial epithelium. A variably abundant clear to collagenous matrix separated the neoplastic cells, which had scant to moderate, fibrillar, frequently vacuolated eosinophilic cytoplasm with indistinct borders. The nuclei of these cells were irregularly round to oval with blunt ends, stippled chromatin and indistinct nucleoli. There was moderate nuclear and cellular pleomorphism, with pleomorphic cells that were more abundant in the larger masses. A few lymphocytes, plasma cells, macrophages, and hemosiderophages were scattered among the spindle cells. Several macrophages that contained darkbrown pigment were also present within the epithelium and superficial portions of the masses. Based on the hitopathological findings, this case was diagnosed as a uterine leiomyosarcoma in a Mongolian gerbil.
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KEYWORD
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Leiomyosarcoma, uterine muscle, uterus tumor, Mongolian gerbil
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