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KMID : 1204320090250010079
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Laboratory Animal Research
2009 Volume.25 No. 1 p.79 ~ p.85
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Current Status of the Management Program for Animal Model of Disease in an Advanced Country
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Lee Yoen-Kyung
Jung Seung-Eun
Kim Ji-Ha
Kim Ji-Eun
Kang Hyun-Ku
Cho Jung-Sik
Suh Jun-Gyo
Hwang Dae-Youn
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Abstract
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Animal models of disease are animals that mimic the pathological condition or the disease entity of specific diseases occurring in humans. These animals are very useful to screen drugs that may be harmful, have a side effect, or would allow a better understanding of the disease mechanism. This study surveyed the current situation of animal care and use program for the Genetic Engineered Mouse (GEM) in the possession of advanced country. Also, the items of these situation involved the GEM number, the national policy and the government support system. The largest number of disease animals in the world is maintained in the USA. Specifically, the National Institute of Health (NIH) in USA supports the several institutions such as Mutant Mouse Regional Resource Centers (MMRRC), Induced Mutant Resource (IMR), Mouse Mutant Gene Resource (MMR), Special Mouse Strains Resource (SMSR) and Neuromice (NMICE) to maintain the animal models of disease. In Japan, RIKEN BioResource Center as one of several resources centers is collecting, supplying and reserving GEM involving the animal models of disease. These works were supported by National BioResource Project (NBRP) of Japanese government. Finally, the some countries in the European Union compile theEuropean Mouse Mutant Archive (EMMA) in order to effectively support and manage these animal models of disease. At present, EMMA possesses 800 kinds of GEM disease models. Therefore, these results suggested that it is very important to establish the national management program for animal model of disease, and this system must be established as soon as possible in our country.
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KEYWORD
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Disease model, MMRRC, NBRP, EMMA
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