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KMID : 1204320090250020167
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Laboratory Animal Research
2009 Volume.25 No. 2 p.167 ~ p.172
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Effect of 2,3,4,4’,5-pentachlorobiphenyl (PCB 114) on Morphological Changes in the Testis of the Rats
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Kim Gon-Sup
Park Oh-Sung
Kim Mun-Ki
Koh Pil-Ok
Cho Jae-Haen
Won Chung-Kil
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Abstract
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This study was performed to examine the effect of 2,3,4,4’,5-pentachlorobiphenyl (PCB 114) on morphological changes in the testes of rats. PCB 114 (20 mg/kg/week) in corn oil was intraperitoneally injected into adult rats for 2, 5, and 8 weeks, with injections carried out weekly. The total body weights and testicular weights were measured at 3, 6, and 9 weeks during PCB treatment, respectively. The morphological changes in the rat testes were then analyzed by light microscopy (LM) and transmission electron microscopy (TEM). The results showed that PCB 114 caused no significant change in the body weight but caused a marked increase in the testicular weights at 6 weeks. The LM results proved that the size of their seminiferous tubules slightly increased by PCB treatment, and cytoplasmic vacuolation and damaged nuclear membrane of spermatogenic cells were evident at 6 weeks in the electon microscopical examination. These results suggest that the reproductive of the adult male rats is effective to PCB 114, and that may induce degenerative changes in testicular parenchyma of adult male rats.
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KEYWORD
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Pentachlorobiphenyl, rat, testis, testicular degeneration
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