|
KMID : 1204320090250030207
|
|
Laboratory Animal Research
2009 Volume.25 No. 3 p.207 ~ p.212
|
|
|
UG0712, A Novel Ginsenoside Composition Enhances the Endurance Exercise Capacity and Fatigue Recovery
|
|
Chai Hee-Youl
Lee Young-Chul
Woo Sung-Sick
Kang Jong-Koo
Do Seon-Gil
Kim Jong-Han
Kim Dong-Seon
Sung Soo-Kyung
|
|
|
Abstract
|
|
|
|
A novel composition of ginsenosides with high Rd and Rg3 content, UG0712 was evaluated for exercise capacity, and post-exercise fatigue recovery through in vivo treadmill maximum running test (MRT) under continuous training (n=9) or resting (n=10) conditions of the SD rats. The standardized ginseng root extract (UG0714) was used for efficacy comparison. Each animal was treated orally at the dose of 25 ㎎/ ㎏ for 8 weeks in exercise group or 9 weeks in resting group. Blood lactate dehydrogenase (LDH) activity and lactic acid concentration were measured to evaluate the post-exercise fatigue recovering effect after exhausted exercise. MRT of UG0712 group showed statistically significant 27.8% increase at week two (P＜0.05) and maintained at an increased level in 8-weeks (27.6% increase, not significance) compared with vehicle treated control group. In resting group, MRT of UG0712 after 8-weeks treatment showed 23.0% increase compared with vehicle group (P＜0.05) and 23.5% increase when compared with UG0714 group (P＜0.05). While no significant changes were found in UG0714 group under either exercise or resting conditions. UG0712 group showed significantly decreased blood LDH levels compared with both vehicle (P＜0.01) and UG0714 (P＜0.05) groups under trained condition but no significant changes in resting condition. In addition, UG0712 significantly decreased blood lactic acid levels in trained (P＜0.01) group, while UG0714 showed no significant changes. Considering the evaluation results from both exercise capability and post-exercise fatigue recovery status, it can be concluded that administration of a standardized Rd and Rg3 ginsenoside composition, UG0712 improves endurance exercise performance probably via increased aerobic energy metabolism, and accelerated post-exercise fatigue recovery.
|
|
|
KEYWORD
|
|
|
Ginsenoside complex, endurance exercise, fatigue recovery
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
 
|