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KMID : 1204320090250030225
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Laboratory Animal Research
2009 Volume.25 No. 3 p.225 ~ p.232
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Effects of Herbal Extracts on Hair Growth in an Animal Model of C3H/HeJ Mice
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Kim Jong-Deok
Hue Jin-Joo
Kang Bong-Su
Kim Jun-Hyeong
Nam Sang-Yoon
Yun Young-Won
Kim Jong-Soo
Lee Beom-Jun
Jeong Jae-Hwang
Kim Young-Chul
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Abstract
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This study was carried out to investigate a promoting effect of herbal extracts on hair regrowth in C3H/ HeJ mice. The herbal extracts included the mixture of water and alcohol extract from Eclipta prostrata, Mori cortex radicis, Thujae orientalis folium, and Drynaria fortunei Smith. There were four experimental groups including distilled water (DW), 10% ethanol (EtOH, a vehicle control), 3% minoxidil (MXD, a positive control), and the herbal extract (HE). The animals were shaved with an electric clipper and the test solutions were applied with 0.2 mL volume to the dorsal skin of each mice for 3 weeks. The photograph of hair regrowth was taken at day 0, 4, 7, 10, 14, 17, and 21, and the hair regrowth was evaluated by a scoring index. MXD and HE accelerated hair regrowth after their applications for 10 days, compared to DW or EtOH. An increase in the number and elongation of hair follicles in MXD and HE groups were obviously found in the skin. The activities of alkaline phosphatase and γ-glutamyl transpeptidase were significantly increased by the applications of MXD and HE, compared to DW or EtOH group (P<0.05). The expressions of epidermal growth factor and vascular endothelial growth factor were also significantly higher in MXD and HE groups than DW or EtOH group (P<0.05). These results suggest that the herbal extract used in this study may have a promoting effect on hair regrowth by increasing activities of ALP and γ-GT and expression of EGF and VEGF.
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KEYWORD
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Herbal extract, hair growth, minoxidil, ALP, γ-GT, EGF, VEGF
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