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KMID : 1204320090250030263
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Laboratory Animal Research
2009 Volume.25 No. 3 p.263 ~ p.267
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Development of Isolators for Gnotobiotic Miniature Pig
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Lee Young-Ah
Cho Yoon-Ju
Kim Jong-In
Lee Jae-Won
Han Jin-Soo
Lee Byeong-Han
Nho Whan-Gook
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Abstract
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Miniature pigs have been marked as a source of providing organs for xenotransplantation because they are similar with humans in the physiological structure, organ size and physiological state. Though the demands for gnotobiotic pigs are increasing by the rise of bio-organic researches, there are currently few facilities for producing miniature pigs gnotobiotically. Therefore the isolator only for the miniature pigs is essential for a production and study of the gnotobiotic miniature pigs. By utilizing the isolator for gnotobiotic miniature pigs, caretakers don’t have to take complicated sterilization or pasteurization steps, and thus it reduces the risk of contamination. And it is further expected to have economically positive effects by reducing costs compared to a small scaled gnotobiotic breeding facility. We developed two models of isolator and applied to patents. Weighing balance and partition were installed in the isolator to perform the body weight and temperature measurement, injection and blood-collection more comfortably without any contamination, and it could minimize the stress of animal. It is easy and comfortable to handle miniature pigs using these isolators and expected to be very useful for the study of gnotobiotic pigs.
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KEYWORD
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Gnotobiotic, miniature pig, isolator
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