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KMID : 1204320090250040323
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Laboratory Animal Research
2009 Volume.25 No. 4 p.323 ~ p.328
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A Correlation of Intravascular Bonghan Ducts with Blood Coagulation in Heparinized Swine Model
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Cho Sung-Jin
Lee Hyun-A
Kim Ok-Jin
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Abstract
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During a last decade, there have been considerable reports of novel threadlike structures (NTSs) in mammals. The NTSs are thought to be a part of the Bonghan ducts (BHD) system, which is described as a newly-discovered circulatory system. Networks of BHD system are completely different from blood vessels or lymphatic system in animal and human. To demonstrate intravascular NTSs, it is necessary to verify that the NTSs are not fibrin structures as well as non-coagulations in the blood vessels. We have studied about the correlation between detection of intravascular BHD and blood coagulation. We used 8 pigs for this study, sacrificed them under anesthesia and then compare the fibrin deposition and the intravascular NTSs. The group 1 (n=4) was treated intravenously with heparin (500 U/㎏) IV for anticoagulation, but the group 2 (n=4) was not. After necropsy of the pigs, we surveyed the NTSs in the aorta, vena cava, atriums, ventricles and body cavities. As results, we only observed intravascular NTSs in the group 2, but were not detected in group 1, moreover the detection of NTSs was often time consuming. In the results of group 2, we could detect the NTSs in more than 5 minutes after necropsy. Thus, we considered that the NTSs structures were suspected to be the coagulated fibrosis. On the basis of this study, intravascular NTSs and Bonghan ducts system were likely to be closely related to fibrinosis.
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KEYWORD
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Novel threadlike structures, Bonghan duct, fibrin, pig
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