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KMID : 1204320090250040329
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Laboratory Animal Research
2009 Volume.25 No. 4 p.329 ~ p.333
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Fermentation Filtrate of Sweet Potato Improves the Male Reproductive Function ex Vivo and in Vivo
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Jeon Jeong-Hee
Jang Ja-Young
Park Dong-Sun
Joo Seong-Soo
Kang Hyo-Min
Kim Sung-Hyun
Kim Yun-Bae
Shin Sun-Hee
Oh Ji-Young
Hwang Seock-Yeon
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Abstract
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The effects of anthocyanins (SPA) and liquid (SPL) fractions from fermentation filtrate of sweet potato on the male reproductive function were investigated ex vivo and in vivo. In ex vivo study, we determined whether the candidate fractions relax isolated New Zealand white rabbit corpus cavernosum, which was precontracted by phenylephrine (5×10?? M). The results revealed that SPL exerted a concentrationdependent relaxing effect, leading to a median effective concentration (EC??) of 1.12 ㎎/mL, which was superior to SPA (EC?? ≒4.78 ㎎/mL). For the in vivo study, male ICR mice were orally administered SPL (100 ㎎/㎏) for 28 days, and the reproductive organ weights, serum testosterone level, sperm counts and motility were analyzed. SPL remarkably increased the testes and epididymides weights as well as blood testosterone level. In addition, SPL markedly increased both the testicular and epididymal sperm counts, although it did not affect the sperm motility. The results suggest that unknown ingredients in SPL other than anthocyanins have positive effects on the function of the male reproductive system by triggering penile erection, enhancing blood testosterone level, and increasing sperm counts.
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KEYWORD
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Sweet potato, male reproductive function, penile erection, testosterone, sperm counts
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