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KMID : 1204320100260010001
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Laboratory Animal Research
2010 Volume.26 No. 1 p.1 ~ p.6
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Anti-hepatofibrogenic Effect of Turnip Water Extract on Thioacetamide-induced Liver Fibrosis
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Li Lan
Lee Min-Jae
Park Seung-Kee
Lee Yun-Lyul
Park Dae-Hun
Li Yong-Chun
Choi Hyon-Min
Han Dae-Sup
Yang Hyuck-Joo
Lee Eun-Hye
Jang Hyung-Kwan
Kim Young-Jin
Jang Ja-June
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Abstract
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Liver fibrosis is a chronic liver disease and lots of people in Korea are suffered. There are many efforts to find candidates to suppress liver fibrogenesis and several chemical-induced model or bile duct ligation model have been used to research and develop hepatic fibrogenic suppressor. From the previous study about functional effects of turnip which cultivated in Kangha Island, we got the feasibility which turnip might be able to inhibit heptatic fibrogenesis. TAA is a representative hepatic fibrosis inducer, repeated 7- weeks i.p. injection of it results in hepatic fibrosis. We compared the level of hepatic fibrosis in TAAturnip group, TAA group, and vehicle control group. Nodules-formed by TAA were observed; they were rarely shown in vehicle control group, observed in most area in TAA group, but only shown in periportal regions in TAA-turnip group. These results were confirmed through Masson’s trichrom stain; fibrous structures increased in TAA group (fibrosis score: 4) but significantly decreased in TAA-turnip group (fibrosis score: 2-3). In conclusion, we got the result that turnip water extract has a potency to protect TAA-induced hepatic fibrogenesis but it is necessary further study to find its mechanism.
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KEYWORD
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Turnip water extract, thioacetamide(TAA), hepatofibrogenic animal model, nodular formation
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