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KMID : 1204320100260020153
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Laboratory Animal Research
2010 Volume.26 No. 2 p.153 ~ p.164
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Reference Data of the Main Physiological Parameters in Control Sprague-Dawley Rats from Pre-clinical Toxicity Studies
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Han Zhong-Ze
Zhang Hu-Song
Kim Kwang-Ho
Bae Jin-Sook
Lee Hyun-Kul
Park Chan-Koo
Song Si-Whan
Gil Ki-Hyun
Ahn Tae-Hwan
Kim Kap-Ho
Lee Joo-Young
Xu Hong-De
Lee Ji-Young
Woo Su-Jung
Yoo Hyun-Jung
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Abstract
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The purpose of this paper is to provide reference data related to the body weight, food & water consumptions, urinalysis, hematology and serum biochemistry parameters and absolute & relative organ weights obtained from control Sprague-Dawley rats, used in the 4-week and 13-week repeated-dose toxicity studies conducted in our laboratory between 2005 and 2008. The mean, standard deviation, minimum and maximum range values for hematology and serum biochemistry parameters, data of absolute & relative organ weights, and the difference between sexes and study duration of week 4 versus 13 week are presented. The studies were conducted according to “the standards of Toxicity Study for Medicinal Products” (2005) and The KFDA Notification No. 2000-63 ‘Good Laboratory Practice (GLP)’ (2000) issued by KFDA. These data could be used as reference material of Sprague-Dawley rats by conducting the studies to evaluate the toxicological profile of pre-clinical toxicity studies.
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KEYWORD
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Hematology, reference data, Sprague-Dawley rat, pre-clinical toxicity studies
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