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KMID : 1204320100260030225
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Laboratory Animal Research
2010 Volume.26 No. 3 p.225 ~ p.232
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Neuronal Hyperexcitability Mediates Below-Level Central Neuropathic Pain after Spinal Cord Injury in Rats
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Park Eun-Sung
Jeon Young-Hoon
Cho Dae-Chul
Youn Dong-Ho
Gwak Young-Seob
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Abstract
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Spinal cord injury often leads to central neuropathic pain syndromes, such as allodynic and hyperalgesic behaviors. Electrophysiologically, spinal dorsal horn neurons show enhanced activity to non-noxious and noxious stimuli as well as increased spontaneous activity following spinal cord injury, which often called hyperexcitability or central sensitization. Under hyperexcitable states, spinal neurons lose their ability of discrimination and encoding somatosensory information followed by abnormal somatosensory recognition to non-noxious and noxious stimuli. In the present review, we summarize a variety of pathophysiological mechanisms of neuronal hyperexcitability for treating or preventing central neuropathic pain syndrome following spinal cord injury.
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KEYWORD
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Central neuropathic pain, hyperexcitability, rat model
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