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KMID : 1204320100260030265
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Laboratory Animal Research
2010 Volume.26 No. 3 p.265 ~ p.271
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Inhibitory Effects of Korean Red Ginseng Extract on Atopic Dermatitis in NC/Nga Mice
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Kim Hyo-Sang
Oh Tae-Ho
Song Jae-Chan
Kim Dae-Ik
Lim Ae-Kyung
Yang Deok-Chun
In Jun-Gyo
Kim Young-Chul
Kim Kil-Soo
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Abstract
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Atopic dermatitis (AD) is a chronic eczematous skin disease attended by pruritus, erythema, edema, excoriation, and dryness. This study was to evaluate the effects of Korean red ginseng (RG) on AD in NC/Nga mice treated with 1-chloro-2,4,6-trinitrobenzene (picryl chloride; PC). Experimental groups were divided into 4 groups; normal control (NC), PC control, and PC-RG (50 and 100 mg/kg). RG was orally administered every day repeatedly during 6 weeks. The skin lesions in severity score, scratching behavior, serum immunoglobulin E (IgE), interleukin-4 (IL-4) and interferon-γ (IFN-γ) levels, and histological appearance were examined. AD-like lesions were developed on the NC/Nga mice by topical PC applications. Oral administration of RG (50 and 100 mg/kg) significantly suppressed the development of AD, as analyzed by a modified SCORAD score. The scratching behavior decreased after RG administration. The levels of serum IgE, IL-4 and IFN-γ were increased by PC stimulation, but treatment with RG (100 ㎎/㎏) suppressed the increment of the serum IgE, IL-4 and IFN-γ levels. Histologically, RG inhibited dermatitis lesions such as hypertrophy, hyperkeratosis, and infiltration of inflammatory cells into epidermis and dermis. These results suggest that the administration of RG may be effective in alleviating the AD induced by PC.
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KEYWORD
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Korean red ginseng, NC/Nga mice, atopic dermatitis, picryl chloride
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