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KMID : 1204320100260030279
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Laboratory Animal Research
2010 Volume.26 No. 3 p.279 ~ p.286
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Enhancement of Exercise Capacity by Black Ginseng Extract in Rats
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Jo Gyeong-Seok
Chai Hee-Youl
Ji Hyeong-Jin
Kang Mi-Hyun
Kang Shin-Jyung
Ji Joong-Gu
Kim Dae-Joong
Lee Beom-Jun
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Abstract
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This study was carried out to investigate an enhancing effect of black ginseng extract (BGE) on exercise capacity in an endurance exercising animal model. Fifty Sprague-Dawley rats were assigned to 5 experimental groups including non-training control, training control, and 3 treated groups (BGE at doses of 75, 150 and 300 ㎎/㎏). The animals were treated with BGE for 6 weeks and their exercise ability in the maximal running distance test was determined using a treadmill every week. The blood lactic acid (LA) level and the activity of citrate synthase (CS) in the muscle were also measured after the exercise. The levels of glucose and glucose-6-phosphate (G-6-P) in the liver and muscle were determined using commercial assay kits. BGE treatments at the doses of 150 and 300 ㎎/㎏ significantly increased the exercise capacity compared with the non-training control or training control groups (P＜0.05). The level of blood LA was decreased but the activity of CS was increased by the treatment of BGE at the dose of 300 ㎎/㎏ compared with the training control group. The level of G-6-P in the liver was elevated by the treatment of BGE at the dose of 300 ㎎/㎏, compared to the training group. As compared with nontraining control group, the treatments of BGE increased the levels of glucose and G-6-P in the liver and soleus muscle of rats. These results indicate that BGE have a potential for promoting exercise capacity by increasing CS activity in the muscle and decreasing LA in the serum of rats. These results also suggested that BGE can be used as a candidate supplement of health food products for promoting endurance exercise capacity in human athletes.
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KEYWORD
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Black ginseng extract, ginseng saponins, exercise capacity, glucose, citrate synthase, lactic acid
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