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KMID : 1204320100260030315
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Laboratory Animal Research
2010 Volume.26 No. 3 p.315 ~ p.318
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Morphometric Analysis of Tibial Bone in Three Strains of Mice Using Micro-computed Tomography
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Ahn Byung-Su
Kim Joong-Sun
Lee Chang-Geun
Yang Mi-Young
Moon Chang-Jong
Kim Jong-Choon
Jung U-Hee
Kim Sung-Ho
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Abstract
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This study investigated the trabecular and cortical bone microarchitecture of tibia in 14-week-old C3H/HeN, C57BL/6J and ICR mice using micro-computed tomography (micro-CT). Defined volumes of interest were scanned at a resolution of 17 ㎛ (isotropic). The X-ray tube was set at photon energy of 50 ㎸, current of 200 ㎂, exposure time 1.2 sec, and a 0.5 ㎜-thick aluminium filter. For quantification of bone mineral density (BMD), the bone samples were scanned by micro-CT together with 2 calibration phantoms. The image slices were reconstructed using 3-dimensional CT analyzer software. C3H/HeN mice showed significantly higher levels of bone volume fraction, trabecular number and BMD, and lower levels of trabecular separation, structure model index and degree of anisotropy compared to C57BL/6J or ICR mice in trabecular bone area. So the C3H/HeN mouse appeared to be a good model animal for the study on the changes of trabecular bone with high trabecular bone mass.
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KEYWORD
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Micro-computed tomography, trabecular bone, microarchitecture, mouse strain
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