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KMID : 1204320100260040361
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Laboratory Animal Research
2010 Volume.26 No. 4 p.361 ~ p.367
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Dangyuja (Citrus grandis Osbeck) Peel Improves Lipid Profiles and Alleviates Hypertension in Rats Fed a High-Fat Diet
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Hong Hyun-Ju
Jin Ju-Youn
Yang Hee-Kyoung
Kang Won-Young
Kim Dong-Geon
Lee Sun-Yi
Choi Young-Hun
Kim Jae-Hoon
Han Chang-Hoon
Lee Young-Jae
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Abstract
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Obesity is a major public health problem and significant risk factor for many serious diseases including coronary artery disease, cancer, and diabetes. This study was performed to investigate the hypolipidemic effects and anti-hypertensive effect of Dangyuja (Citrus grandis Osbeck) peel, which is bred on Jeju island, in rats fed a high-fat diet. This study was conducted on 4 equal rat groups which were fed as follows; normal diet group (ND), high fat diet group (HFD), high fat diet supplemented with powdered peel of Dangyuja (1%, wt/wt) group (HFD+Dangyuja), and high fat diet treated with sibutramine simultaneously at a dose of 10 ㎎/㎏ group (HFD+Sibutramine). After feeding the high fat diet, body weight gain and relative weight of adipose tissues and liver significantly increased in HFD group, but Dangyuja peel supplementation protected these HFD-induced changes. The levels of serum triglyceride, total cholesterol, low-density lipoprotein (LDL)-cholesterol, and the atherogenic index significantly decreased in the HFD+Dangyuja peel group compared with the HFD group. The systolic blood pressure was significantly increased by feeding the high fat diet, whereas the supplementation of Dangyuja peel effectively prevented the elevation of blood pressure. Therefore, these results suggest that Dangyuja exerts a beneficial effect on obesity by improving lipid metabolism and alleviating obesity-related hypertension.
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KEYWORD
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Dangyuja, high-fat diet, obesity, cholesterol, hypertension
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