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KMID : 1204320100260040377
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Laboratory Animal Research
2010 Volume.26 No. 4 p.377 ~ p.384
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The Symptoms of Atopic Dermatitis in NC/Nga Mice Were Significantly Relieved by the Water Extract of Liriope platyphylla
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Kim Ji-Eun
Lee Yoen-Kyung
Nam So-Hee
Choi Sun-Il
Goo Jun-Seo
Jang Min-Ju
Lee Hee-Seob
Son Hong-Ju
Lee Chung-Yeol
Hwang Dae-Youn
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Abstract
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Atopic dermatitis is an well-known skin disease showing inflammatory, chronically relapsing, noncontagious and pruritic symptoms. The aims of this study were to investigate the effects of Liriope platyphylla (LP) on atopic dermatitis of NC/Nga mice. To achieve this, NC/Nga mice were treated with four different conditions including vehicle, phthalic anhydride (PA), PA+5% LP and PA+10% LP, and the changes of immune-related factors were detected after 2 weeks. The pathological phenotypes of atopic dermatitis such as erythema, ear thickness, edema, scab and discharge were significantly decreased in PA+10% LP cotreated groups compare to PA treated group. Also, the weight of lymph node and thymus in immune organs were gradually decreased in LP treated groups, while the weight of spleen was slightly increased in same group. Furthermore, toluidine blue staining analysis, a method used to specifically identify the mast cell, showed that the decrease of master cell infiltration into the dermis were statistically observed in PA+5% LP and PA+10% LP5% cotreated groups. Especially, the decrease of IgE concentration was detected only PA+10% LP cotreated group, although this level was maintained in PA+5% LP cotreated group. Therefore, these results suggested that the water extracts of LP may contribute the relieve of atopic dermatitis symptoms and be considered as an excellent candidate for a atopic dermatitis-therapeutic drug.
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KEYWORD
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Atopic dermatitis, Liriope platyphylla, mast cell, IgE, ear thickness
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