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KMID : 1204320100260040407
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Laboratory Animal Research
2010 Volume.26 No. 4 p.407 ~ p.413
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Antioxidative and Antidiarrheal Effects of Persimmon Extracts
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Park Dong-Sun
Lee Sun-Hee
Bae Dae-Kwon
Choi Young-Jin
Kim Tea-Kyun
Yang Yun-Hui
Yang Go-Eun
Kwon Sang-Chul
Lee Do-Ik
Joo Sung-Soo
Kim Yun-Bae
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Abstract
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Since oxidative stresses are involved in gastroenteritis and diarrhea, we investigated antioxidative and antidiarrheal activities of persimmon flesh extract (PFE) and persimmon calyx extract (PCE) in vitro and in vivo, respectively. PCE significantly scavenged 1,1-diphenyl-2-picrylhydrazyl hydrate and 2,2"-azinobis (3-ethylbenzthiazoline-6-sulfonic acid) from 500 ㎍/mL, although PFE was ineffective. In addition, PFE and PCE exhibited strong nitric oxide-scavenging effects from 1 μg/mL, in which PCE was superior to ascorbic acid (50 μM). Furthermore, PFE and PCE significantly inhibited FeCl3-induced lipid peroxidation as well as Cu2+/H₂O₂-induced protein oxidation from 10 μg/mL. In vivo charcoal-propulsion assay, in contrast to a negligible effect of PFE, treatment with PCE (160-500 ㎎/㎏) markedly inhibited intestinal motility. The results indicate that extracts of persimmon, especially PCE, possess antioxidative, antiinflammatory and antidiarrheal activities. Therefore, it is suggested that persimmon extracts could be used for the relief of gastroenteritis and diarrhea.
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KEYWORD
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Persimmon, antioxidative activity, antidiarrheal activity, gastrointestinal motility
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