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KMID : 1204320110270010041
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Laboratory Animal Research
2011 Volume.27 No. 1 p.41 ~ p.46
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Mapping of the Faded (fe) Gene to a Region between D10mit191 and D10mit44 on Mouse Chromosome 10
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Oh Seung-Hun
Nam Yoon-Yi
Suh Jun-Gyo
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Abstract
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The faded mouse is a coat color mutant that shows faded coat color and age-related loss of pigmentation. This mutation is transmitted by an autosomal recessive gene with 100% penetrance. In the present study, we carried out linkage analysis of the faded (fe) gene using intra-specific backcross panels. Affected faded mice were carefully confirmed by their faded coat color at about 4 weeks of age. In the intra-specific backcross between faded and CBA mice (n=198), the fe gene was mapped to a region 2.1 cM distal to D10mit191. Therefore, the gene order was defined as follows: centromere-D10mit51 (12.4±2.4 cM)-D10mit191 (2.1±1.0 cM)-fe-D10mit44 (13.3±2.4 cM)-D10mit42 (14.4±2.5 cM). This linkage map of the fe locus will provide a good entry point to isolate the fe gene. Since the faded mouse has pigmentary abnormalities, this mutant may be a useful model for studies of pigmentary abnormalities in humans.
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KEYWORD
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Genetic mapping, linkage analysis, faded gene, chromosome 10
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