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KMID : 1204320110270010067
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Laboratory Animal Research
2011 Volume.27 No. 1 p.67 ~ p.71
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Neuroprotection of Alpinia katsumadai Seed Extract against Neuronal Damage in the Ischemic Gerbil Hippocampus is Linked to Altered Brain-Derived Neurotrophic Factor
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Li Hua
Park Joon-Ha
Yan Bing Chun
Yoo Ki-Yeon
Lee Choong-Hyun
Choi Jung-Hoon
Hwang In-Koo
Won Moo-Ho
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Abstract
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The extract of Alpinia katsumadai, a member of the family Zingiberaceae, shows anti-inflammatory effects and antioxidant activity. We observed the neuroprotective effects of the extract from Alpinia katsumadai seed (EAKS) against ischemic damage in gerbils administered oral EAKS (25, and 50 ㎎/㎏) once a day for 7 days before transient cerebral ischemia. In the 50 ㎎/㎏ EAKS-treated ischemia group, about 67% of neurons in the hippocampal CA1 region (CA1) survived after ischemia/reperfusion (I/R) based on cresyl violet staining. We observed that EAKS treatment significantly maintained brain-derived neurotrophic factor (BDNF) immunoreactivity in the ischemic CA1 region after I/R. In addition, protein levels of BDNF in the 50 ㎎/㎏ EAKS-treated ischemia group were much higher than those in the vehicle-treated ischemia group after I/R. These findings indicate that repeated supplementation of EAKS protects neurons from ischemic damage, such that BDNF is distinctively maintained in ischemic areas.
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KEYWORD
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Transient cerebral ischemia, Zingiberaceae, neuroprotection, brain-derived neurotrophic factor
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