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KMID : 1204320110270030181
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Laboratory Animal Research
2011 Volume.27 No. 3 p.181 ~ p.187
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Microglia in the normally aged hippocampus
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Choi Jung-Hoon
Won Moo-Ho
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Abstract
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The hippocampus plays important roles in the regulation and combination of short and long term
memory and spatial navigation with other brain centers. Aging is accompanied by a functional decline of
the hippocampus and degenerative disease. Microglia are major immune cells in the central nervous
system and response to degenerative changes in the aged brain. In this respect, functional and
morphological changes of the hippocampus have been closely related to microglial changes during
normal aging with or without disease. Therefore, in this review, we discuss morphological and functional
changes of the hippocampus and microglia in the aging brain.
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KEYWORD
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Aging, brain, memory, immune cells
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