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KMID : 1204320120280020115
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Laboratory Animal Research
2012 Volume.28 No. 2 p.115 ~ p.121
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Historical control data from 13-week repeated toxicity studies in Crj:CD (SD) rats
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Lee Jung-Min
Lee Min-Ah
Do Hyeon-Nam
Bae Re-Ji-Na
Lee Hye-Yeong
Park Sun-Hee
Kang Jin-Seok
Kang Jong-Koo
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Abstract
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Reference ranges of standard experimental parameters are useful for comparisons in toxicology. The aim of this study was to collect data from 13-week repeated toxicity studies in Crl:CD (SD) rats, a strain widely used for toxicity and efficacy research, for establishing domestic reference values. Data on body weight, food consumption; urinalysis, hematological, and blood biochemical parameters; and organ weights were collected from 11 toxicity studies in 220 Crl:CD (SD) rats (110 males and 110 females). The studies had been performed at a single testing facility over the last 5 years and involved animals sourced from a single breeder. The findings were collated as means, standard deviations, percentages, and ranges. Urine volume, uterus weight, eosinophil, and basophil counts, and triglyceride, total bilirubin, and gamma-glutamyl transpeptidase levels showed standard deviations of 30% or more. These historical control data would help to interpret the effects of test substances in routine toxicity and efficacy studies.
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KEYWORD
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Crj:CD (SD) rat, control data, reference range, toxicology
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