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KMID : 1204320120280020123
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Laboratory Animal Research
2012 Volume.28 No. 2 p.123 ~ p.129
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Anti-hyperlipidemic effect of soybean extract fermented by Bacillus subtilis MORI in db/db mice
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Nam Yoon-Yi
Jung Ha-rry
Karuppasamy Sankarapandian
Lee Jae-Yeon
Kang Kyung-Don
Hwang Kyo-Yeol
Seong Su-Il
Suh Jun-Gyo
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Abstract
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The purpose of this study was to investigate the anti-hyperlipidemic effect of soy bean extract solution fermented by Bacillus subtilis MORI (BTD-1E) in obese db/db mice. Eight-week-old male db/db mice were administered 33.3 mg/kg BTD-1E solution orally once a day for four weeks. The BTD-1E group showed significantly lower body weight compared with the db control group (P<0.05). The BTD-1E group showed significantly lower serum total cholesterol and LDL cholesterol levels compared with the db control group, respectively (P<0.05, P<0.01). The BTD-1E group showed significantly decreased liver weight relative to final body weight compared with the db control group (P<0.01). After four weeks of BTD-1E administration, lipid droplets in the liver were apparently decreased in the BTD-1E group compared to the db control group. In summary, our results suggest that BTD-1E has an anti-hyperlipidemic effect in the obese mouse model.
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KEYWORD
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Fermented soybean extract, Bacillus subtilis MORI, 1-deoxynojirimycin, lipid-lowering effect, anti-obesity
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