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KMID : 1204320120280020137
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Laboratory Animal Research
2012 Volume.28 No. 2 p.137 ~ p.140
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Anti-inflammatory effects of Houttuynia cordata supercritical extract in carrageenan-air pouch inflammation model
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Kim Da-Jeong
Park Dong-Sun
Kyung Jang-Been
Yang Yun-Hui
Choi Ehn-Kyoung
Lee Yoon-Bok
Kim Hyun-Kyu
Hwang Bang-Yeon
Kim Yun-Bae
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Abstract
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Anti-inflammatory effects of Houttuynia cordata supercritical extract (HSE) were investigated in rat carrageenan-air pouch model. Oral administration of HSE (50-200 mg/kg) suppressed carrageenan-induced exudation and albumin leakage, as well as inflammatory cell infiltration at a high dose (200 mg/kg). Intraperitoneal injection of dexamethasone (2 mg/kg) only decreased exudation and cell infiltration, while indomethacin (2 mg/kg, i.p.) reduced exudate volume and albumin content without influence on the cell number. HSE lowered tumor-necrosis factor-α (TNF-α) and nitric oxide (NO), as well as prostaglandin E2 (PGE2). Dexamethasone only reduced TNF-α and NO, while indomethacin decreased PGE2. The results indicate that HSE exhibits anti-inflammatory effects by inhibiting both TNF-α-NO and cyclooxygenase-2-PGE2 pathways.
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KEYWORD
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Carrageenan, inflammation, Houttuynia cordata, supercritical extract
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