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KMID : 1204320120280020141
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Laboratory Animal Research
2012 Volume.28 No. 2 p.141 ~ p.145
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Monitoring of antibiotic resistance in bacteria isolated from laboratory animals
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Goo Jun-Seo
Jang Mee-Kyung
Shim Sun-Bo
Jee Seung-Wan
Lee Su-Hae
Bae Chang-Jun
Park Song-Hee
Kim Kwang-Je
Kim Ji-Eun
Hwang In-Sik
Lee Hye-Ryun
Choi Sun-Il
Lee Young-Ju
Lim Chul-Joo
Hwang Dae-Youn
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Abstract
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The drug resistance of microorganisms isolated from laboratory animals never treated with antibiotics is being reported consistently, while the number of laboratory animals used in medicine, pharmacy, veterinary medicine, agriculture, nutrition, and environmental and health science has increased rapidly in Korea. Therefore, this study examined the development of antimicrobial resistance in bacteria isolated from laboratory animals bred in Korea. A total of 443 isolates (7 species) containing 5 Sphingomonas paucimobilis, 206 Escherichia coli, 60 Staphylococcus aureus, 15 Staphylococcus epidermidis, 77 Enterococcus faecalis, 27 Citrobacter freundii, 35 Acinetobacter baumannii were collected from the nose, intestine, bronchus and reproductive organs of ICR mice and SD rats. Of these species, Acinetobacter baumannii and Enterococcus faecalis showed significant antimicrobial resistance according to the minimum inhibition concentration (MIC) in E-test. In case of Acinetobacter baumannii, several isolates showed MIC values 16-128 μg/mL for cefazolin and cefoxitin, and higher resistance (128-512 μg/mL) to nitrofurantoin than that of standard type. Resistance to cefazolin, cefoxitin and nitrofurantoin was detected in 17.14, 20.00, and 8.57% of the Acinetobacter baumannii isolates, respectively. In addition, 44.1% of the Enterococcus faecalis isolates collected from the laboratory animals were resistant to oxacillin concentration of 16-32 μg/mL range, while MIC value of standard type was below oxacillin concentration of 6 μg/mL. These results suggest that in rodent species of laboratory animals, Acinetobacter baumannii are resistance to cefazolin, cefoxitin and nitrofurantoin, whereas those of Enterococcus faecalis were resistance to oxacillin.
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KEYWORD
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Drug resistance, Enterococcus faecalis, Acinetobacter baumannii, oxacillin, nitrofurantoin
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