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KMID : 1204320140300010021
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Laboratory Animal Research
2014 Volume.30 No. 1 p.21 ~ p.27
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Perilla oil improves blood flow through inhibition of platelet aggregation and thrombus formation
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Jang Ja-Young
Kim Tae-Su
Cai Jingmei
Kim Ji-Hyun
Kim Young-Eun
Shin Kyung-Ha
Kim Kwang-Sei
Lee Sung-Pyo
Kang Myung-Hwa
Choi Ehn-Kyoung
Rhee Man-Hee
Kim Yun-Bae
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Abstract
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The inhibitory effects of perilla oil on the platelet aggregation in vitro and thrombosis in vivo were investigated in comparison with aspirin, a well-known blood flow enhancer. Rabbit platelet-rich plasma was incubated with perilla oil and aggregation inducers collagen or thrombin, and the platelet aggregation rate was analyzed. Perilla oil significantly inhibited both the collagen- and thrombin-induced platelet aggregations, in which the thromboxane B2 formation from collagen-activated platelets were reduced in a concentration-dependent manner. Rats were administered once daily by gavage with perilla oil for 1 week, carotid arterial thrombosis was induced by applying 35% FeCl3-soaked filter paper for 10 min, and the blood flow was monitored with a laser Doppler probe. Perilla oil delayed the FeCl3-induced arterial occlusion in a dose-dependent manner, doubling the occlusion time at 0.5 mL/kg. In addition, a high dose (2 mL/kg) of perilla oil greatly prevented the occlusion, comparable to the effect of aspirin (30 mg/kg). The results indicate that perilla oil inhibit platelet aggregation by blocking thromboxane formation, and thereby delay thrombosis following oxidative arterial wall injury. Therefore, it is proposed that perilla oil could be a good candidate without adverse effects for the improvement of blood flow.
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KEYWORD
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Platelet aggregation, thromboxane B2, thrombosis, perilla oil
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