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KMID : 1204320140300020090
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Laboratory Animal Research
2014 Volume.30 No. 2 p.90 ~ p.93
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No expression of porcine endogenous retrovirus after pig to monkey xenotransplantation
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Hwang Seong-Soo
Jung Yi-Deun
Ock Sun-A
Oh Keon-Bong
Kim Heui-Soo
Yun Ik-Jin
Ahn Curie
Park Jin-Ki
Im Seo-Ki
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Abstract
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This study was performed to investigate the expression of two porcine endogenous retrovirus (PERV) elements, PERV gag and full-length conserved PERV, in blood cells collected periodically from organ-recipient monkeys that underwent pig to non-human primate xenotransplantation. The heart and kidney-respectively acquired from α-1,3-galactosyltransferase knockout (GT-KO) pigs that survived for24 and 25 days-were xenografted into cynomolgus monkeys. The two PERV elements expressed in the xenografted GT-KO pig organs were not present in the blood cells of the recipient monkeys. In the present study, we deduced that PERVs are not transmitted during GT-KO pig to monkey xenotransplantation.
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KEYWORD
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PERV transmission, GT-KO pigs, cynomolgus monkey, xenotransplantation, blood cells
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