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KMID : 1204320140300030112
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Laboratory Animal Research
2014 Volume.30 No. 3 p.112 ~ p.122
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13-week subchronic toxicity study of a novel ginsenoside composition from ginseng leaves in rats
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Shin Won-Ho
Ri Yu
Do Seon-Gil
Lee Young-Chul
Park Sang-Joon
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Abstract
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UG0712 is a new ginsenoside extract processed from ginseng leaves. A subchronic toxicity study of UG0712 was conducted in male and female SD rats. Rats were treated with UG0712 at doses of 100, 400 and 1,600 mg/kg/day for 13 weeks, and observed followed by 4-week recovery period at a highest dose. No-treatment-related effects were observed regarding the mortality, ophthalmic examination, urinalysis and histopathology. Although the changes in clinical sign, body weight, organ weight, hematology, and serum biochemistry were observed, they were temporal and pharmacological effects. Based on the present experiment conditions, the no observed adverse effect level was considered to be more than 1,600 mg/kg/day in both sexes of rats.
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KEYWORD
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UG0712, ginsenoside extract, ginseng leaf, subchronic toxicity, SD rats
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