|
KMID : 1204320140300030131
|
|
Laboratory Animal Research
2014 Volume.30 No. 3 p.131 ~ p.135
|
|
|
Anti-Helicobacter pylori activities of FEMY-R7 composed of fucoidan and evening primrose extract in mice and humans
|
|
Kim Tae-Su
Cho Ehn-Kyoung
Kim Ji-Hyun
Shin Kyung-Ha
Lee Sung-Pyo
Choi Young-Jin
Jeon Joseph-H.
Kim Yun-Bae
|
|
|
Abstract
|
|
|
|
Helicobacter pylori-eliminating effects of FEMY-R7, composed of fucoidan and evening primrose extract, were investigated in mice and humans. Male C57BL/6 mice were infected with the bacteria by intragastric inoculation (1×109 CFU/mouse) 3 times at 2-day intervals, and simultaneously, orally treated twice a day with 10 or 100 mg/kg FEMY-R7 for 2 weeks. In Campylobcter-like organism-detection test, FEMY-R7 markedly reduced the urease-positive reactivity. In a clinical sudy, human subjects, confirmed to be infected with Helicobacter pylori, were orally administered twice a day with a capsule containing 150 mg FEMY-R7 for 8 weeks. FEMY-R7 significantly decreased both the Delta over baseline-value in urea breath test and the serum pepsinogens I and II levels. The results indicate that FEMY-R7 not only eliminates H. pylori from gastric mucosa of animals and humans, but also improves gastric function.
|
|
|
KEYWORD
|
|
|
Helicobacter pylori, FEMY-R7, fucoidan, evening primrose extract, Campylobcter-like organism-detection test, urea breath test, pepsinogen
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
 
|
|