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KMID : 1204320140300030136
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Laboratory Animal Research
2014 Volume.30 No. 3 p.136 ~ p.141
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Experimental model of tympanic colic (acute abdomen) in chinchillas (Chinchilla lanigera)
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Martinez Pereira Malcon Andrei
Franceschi Raphaela da Cunha
Coelho Barbara Paranhos
Gustavo da Rosa Funkler
Zancan Denise Maria
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Abstract
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Digestive disorders caused by sudden changes in diet or inappropriate diet are among the most common disorders of the digestive system. Cecal or intestinal tympany, one consequence of inappropriate diet, is characterized by the accumulation of gases, marked distension of the cecum and colon and the induction of inflammatory processes. To know the effects of intestinal tympany on the enteric plexuses, we developed a method of experimental tympanic colic (TC) in the Chinchilla lanigera. This species was used in view of its susceptibility to TC. TC was induced with a diet rich in alfalfa associated with grain overload for two weeks. Physical and clinical examination including the von Frey test confirmed the diagnosis. The chinchillas with acute abdomen were treated with 1% ketoprofen and resumption of a balanced diet. Necropsy and histopathological analysis showed tympany-induced alterations mainly in the cecum and colon. After treatment, the control conditions were restored. The TC protocol is proposed as an experimental approach designed to aid the study of the effects of acute intestinal inflammation and obstruction caused by an inappropriate diet.
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KEYWORD
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Intestinal tympany, acute abdomen, bowel inflammation, Chinchilla lanigera
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