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KMID : 1204320160320030171
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Laboratory Animal Research
2016 Volume.32 No. 3 p.171 ~ p.179
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Anti-atherosclerotic effects of perilla oil in rabbits fed a high-cholesterol diet
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Cha Ye-Seul
Jang Ja-Young
Ban Young-Hwan
Guo Hai-Yu
Shin Kyung-Ha
Kim Tae-Su
Lee Sung-Pyo
Choi Ji-Eun
An Eun-Suk
Seo Da-Woom
Yon Jung-Min
Choi Ehn-Kyoung
Kim Yun-Bae
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Abstract
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Anti-atherosclerosis effects of perilla oil were investigated, in comparison with lovastatin, in rabbits fed a high-cholesterol diet (HCD). Hypercholesterolemia was induced in rabbits by feeding the HCD containing 0.5% cholesterol and 1% corn oil, and perilla oil (0.1 or 0.3%) was added to the diet containing 0.5% cholesterol for 10 weeks. HCD greatly increased blood total cholesterol and low-density lipoproteins, and caused thick atheromatous plaques, covering 74% of the aortic wall. Hyper-cholesterolemia also induced lipid accumulation in the liver and kidneys, leading to lipid peroxidation. Perilla oil not only attenuated hypercholesterolemia and atheroma formation, but also reduced fat accumulation and lipid peroxidation in hepatic and renal tissues. The results indicate that perilla oil prevents atherosclerosis and fatty liver by controlling lipid metabolism, and that it could be the first choice oil to improve diet-induced metabolic syndrome.
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KEYWORD
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Hypercholesterolemia, atherosclerosis, fatty liver, lipid peroxidation, perilla oil
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