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KMID : 1204320170330030237
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Laboratory Animal Research
2017 Volume.33 No. 3 p.237 ~ p.243
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Age-dependent differences in myelin basic protein expression in the hippocampus of young, adult and aged gerbils
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Ahn Ji-Hyeon
Lee Tae-Kyeong
Park Joon-Ha
Cho Jeong-Hwi
Kim In-Hye
Lee Jae-Chul
Hong Seong-Kweon
Jeon Yong-Hwan
Kang Il-Jun
Lee Young-Joo
Won Moo-Ho
Lee Choong-Hyun
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Abstract
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Myelin degeneration is one of the characteristics of aging and degenerative diseases. This study investigated age-related alterations in expression of myelin basic protein (MBP) in the hippocampal subregions (dentate gyrus, CA2/3 and CA1 areas) of gerbils of various ages; young (1 month), adult (6 months) and aged (24 months), using western blot and immunohistochemistry. Western blot results showed tendencies of age-related reductions of MBP levels. MBP immunoreactivity was significantly decreased with age in synaptic sites of trisynaptic loops, perforant paths, mossy fibers, and Schaffer collaterals. In particular, MBP immunoreactive fibers in the dentate molecular cell layer (perforant path) was significantly reduced in adult and aged subjects. In addition, MBP immunoreactive mossy fibers in the dentate polymorphic layer and in the CA3 striatum radiatum was significantly decreased in the aged group. Furthermore, we observed similar age-related alterations in the CA1 stratum radiatum (Schaffer collaterals). However, the density of MBP immunoreactive fibers in the dentate granular cell layer and CA stratum pyramidale was decreased with aging. These findings indicate that expression of MBP is agedependent and tissue specific according to hippocampal layers.
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KEYWORD
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Myelin basic protein, aging, hippocampus, gerbil
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