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KMID : 1204320170330040283
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Laboratory Animal Research
2017 Volume.33 No. 4 p.283 ~ p.290
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Dendropanax morbifera Leveille extract ameliorates D-galactoseinduced memory deficits by decreasing inflammatory responses in the hippocampus
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Lee Kwon-Young
Jung Hyo-Young
Yoo Dae-Young
Kim Woo-Suk
Kim Jong-Whi
Kwon Hyun-Jung
Kim Dae-Won
Yoon Yeo-Sung
Hwang In-Koo
Choi Jung-Hoon
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Abstract
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In the present study, we examined the effects of Dendropanax morbifera Leveille leaf extract (DML) on Dgalactose- induced morphological changes in microglia and cytokines, including pro-inflammatory cytokines (interleukin [IL]-1β, IL-6, and tumor necrosis factor [TNF]-α) and anti-inflammatory cytokines (IL-4 and IL-10) in the hippocampus. Administration of DML to D-galactose-treated mice significantly improved D-galactose-induced reduction in escape latency, swimming speed, and spatial preference for the target quadrant. In addition, administration of DML to D-galactose-treated mice significantly ameliorated the microglial activation and increases of IL-1β, IL-6, and TNF-α levels in the hippocampus. Administration of D-galactose significantly reduced IL-4 levels in the hippocampus, while administration of DML to D-galactose-treated mice significantly increased IL-4 level. However, we did not observe any significant changes in IL-10 levels in hippocampal homogenates. These results suggest that DML reduces D-galactose-induced mouse senescence by reducing pro-inflammatory cytokines such as IL-1β, IL-6, and TNF-α, as well as increasing anti-inflammatory cytokine IL-4.
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KEYWORD
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Dendropanax morbifera extract, D-galactose, hippocampus, inflammation, memory
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