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KMID : 1204320190350010029
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Laboratory Animal Research
2019 Volume.35 No. 1 p.29 ~ p.29
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Investigation of the effect of coffee on body weight, serum glucose, uric acid and lipid profile levels in male albino Wistar rats feeding on high-fructose diet
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Feyisa Teka Obsa
Melka Daniel Seifu
Menon Menakath
Labisso Wajana Lako
Habte Mezgebu Legesse
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Abstract
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Coffee is one of the most commonly consumed beverages in the worldwide and is assumed to have protective effects against metabolic syndrome. The present study was aimed at investigating the effect of coffee on body weight, serum glucose, uric acid and lipid profile levels in male albino Wistar rats feeding on high fructose diet. A post-test experimental study was conducted on a total of 30 (9?10?weeks old) male albino Wistar rats. The rats were divided into 6 groups: group I (normal control)-fed on standard chow and plain tap water only; group II (fructose control)-fed on standard chow and 20% of fructose solution; group III?VI (treatment groups)-fed on standard chow, 20% of fructose solution and treated with 71, 142, 213 and 284?mg/kg body weight/day of coffee respectively for six weeks. At the end, body weight, serum glucose, uric acid and lipid profile levels were investigated. Data was entered and cleared by epi-data software version 3.1 and analyzed by one way ANOVA followed by Tukey post hoc multiple comparison tests using SPSS V. 23.00. Statistical significance was considered at p?
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KEYWORD
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Body weight, Coffee, Glucose, High-fructose diet, Lipid profiles, Uric acid
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