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KMID : 1204320200360010029
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Laboratory Animal Research
2020 Volume.36 No. 1 p.29 ~ p.29
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Comparative analysis of restraint stress-induced depressive-like phenotypes in C57BL/6N mice derived from three different sources
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Hwang Dong-Joo
Kwon Ki-Chun
Hwang Dae-Youn
Seo Min-Soo
Kim Kil-Soo
Jung Young-Suk
Cho Joon-Yong
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Abstract
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C57BL/6NKorl mice are a novel mouse stock recently developed by the National Institute of Food and Drug Safety Evaluation in Korea. Extensive research into the nature of C57BL/6NKorl mice is being conducted. However, there is no scientific evidence for the phenotypic response to restraint stress (RST), a stress paradigm for modeling depressive disorders, in rodents. In this study, we investigated the repeated RST-induced depressive-like phenotypes in C57BL/6?N mouse substrains (viz., C57BL/6NKorl mice from Korea, C57BL/6NA mice from the United States, and C57BL/6NB mice from Japan) obtained from different sources. The results showed that C57BL/6?N mice derived from various sources exposed to repeated RST resulted in depressive-like phenotypes reflected by a similar degree of behavioral modification and susceptibility to oxidative stress in a duration-dependent manner, except for the distinctive features (increased body weight (BW) and tolerance to the suppression of BW gain by exposure to repeated RST) in C57BL/6NKorl mice. Taken together, the duration-dependent alteration in depressive-like phenotypes by repeated exposure to RST observed in this study may provide valuable insights into the nature of C57BL/6NKorl mice as an alternative animal resource for better understanding of the etiology of depressive disorders and the mechanisms of antidepressant actions.
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KEYWORD
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C57BL/6NKorl mice, Depressive disorder, Restraint stress
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