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KMID : 1204320210370010017
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Laboratory Animal Research
2021 Volume.37 No. 1 p.17 ~ p.17
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Acute and 28-days subacute toxicity studies of Gαq-RGS2 signaling inhibitor
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Beladiya Jayesh V.
Mehta Anita A.
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Abstract
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Background: The aim of study was to evaluate the single oral dose and 28 day repeated oral administration toxicity profile of the synthetic compound Gαq-RGS2 signaling inhibitor, (1-(5-chloro-2-hydroxyphenyl)-3-(4-(trifluoromethyl)phenyl)-1 H-1,2,4-triazol-5(4 H)-one) as per OECD guideline 425 (2008a) and 407 (2008b), respectively.
Results: In acute toxicity study, a single oral dose administration of Gαq-RGS2 signaling inhibitor did not show any mortality at doses of 5, 50, 300 and 2000 mg/kg within 24 h and 14 days. The treatment of Gαq-RGS2 signaling inhibitor at dose 10 and 100 mg/kg for 28 days did not show any mortality, significant changes in the increase of body weight, various organ damage markers, hematological parameters, relative organ/body weight ratio and microscopic anatomical texture of essential organs as compared to vehicle and normal control.
Conclusions: A single oral administration of Gαq-RGS2 signaling inhibitor up to dose of 2000 mg/kg in mice and repeated administration of Gαq-RGS2 signaling inhibitor at higher dose 100 mg/kg for 28 days in the rats is safe.
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KEYWORD
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Acute toxicity, Sub-acute toxicity, Gαq-RGS2 signaling inhibitor, 28-days repeated dose toxicity, Single oral dose toxicity
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