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KMID : 1204320210370010031
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Laboratory Animal Research
2021 Volume.37 No. 1 p.31 ~ p.31
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Inflammatory response in the mid colon of ICR mice treated with polystyrene microplastics for two weeks
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Choi Yun-Ju
Kim Ji-Eun
Lee Su-Jin
Gong Jeong-Eun
Jin You-Jeong
Seo Sung-Baek
Lee Jae-Ho
Hwang Dae-Youn
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Abstract
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Background: The oral administration of polystyrene-microplastics (PS-MPs) causes chronic constipation of ICR mice, but there are no reports on their effects on the inflammatory response in the colon. To determine if the oral administration of MPs causes inflammation in the colon, the changes in the apoptosis-associated speck like protein containing a caspase recruitment domain (ASC)-inflammasome pathway, nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling pathway, and inflammatory cytokine expression were evaluated in the mid colon of ICR mice treated with 0.5 μm size PS-MPs for two weeks.
Results: The thicknesses of the mucosa, muscle, flat luminal surface, and crypt layer were decreased significantly (p?
Conclusions: Therefore, the present study suggests that PS-MPs can be a novel cause of an inflammatory response in the mid colon of ICR mice.
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KEYWORD
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Microplastics, Inflammation, Colon, NF-κB, Cytokines
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