|
KMID : 1204320220380010035
|
|
Laboratory Animal Research
2022 Volume.38 No. 1 p.35 ~ p.35
|
|
|
Time progression and regional expression of brain oxidative stress induced by obstructive jaundice in rats
|
|
Lilimpakis Konstantinos
Tsepelaki Aidona
Kalaitzopoulou Electra
Zisimopoulos Dimitrios
Papadea Polyxeni
Skipitari Marianna
Varemmenou Athina
Aggelis Apostolos
Vagianos Constantine
Constantoyannis Constantine
Georgiou Christos D.
|
|
|
Abstract
|
|
|
Background: Obstructive jaundice induces oxidative changes in the brain parenchyma and plays significant role in clinical manifestations of hepatic encephalopathy. We aim to study the progression of the brain oxidative status over time and the differences of its pattern over the hemispheres, the brainstem and the cerebellum. We use an experimental model in rats and measuring the oxidative stress (OS) specific biomarkers protein malondialdehyde (PrMDA) and protein carbonyls (PrC?=?O).
Results: Hyperbilirubinemia has been confirmed in all study groups as the result of common bile duct obstruction. We confirmed increase in both PrMDA and PrC?=?O biomarkers levels with different type of changes over time. We also confirmed that the oxidative process develops differently in each of the brain areas in study.
Conclusions: The present study confirms the progressive increase in OS in all brain areas studied using markers indicative of cumulative protein modification.
|
|
|
KEYWORD
|
|
|
Oxidative stress, Obstructive jaundice, Protein oxidation, Protein carbonyls, Rhodamine B hydrazide, Lipid peroxidation
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
 
|