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KMID : 1204320220380010040
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Laboratory Animal Research
2022 Volume.38 No. 1 p.40 ~ p.40
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Anesthesia and analgesia for common research models of adult mice
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Ahmadi-Noorbakhsh Siavash
Abbasi Mohammad Farajli
Ghasemi Maedeh
Bayat Gholamreza
Davoodian Nahid
Sharif-Paghaleh Ehsan
Poormoosavi Seyedeh Mahsa
Rafizadeh Melika
Maleki Maryam
Shirzad-Aski Hesamaddin
Jahromi Hossein Kargar
Dadkhah Masoomeh
Khalvati Bahman
Safari Tahereh
Behmanesh Mohammad Amin
Khoshnam Seyed Esmaeil
Houshmand Gholamreza
Talaei Sayyed Alireza
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Abstract
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Anesthesia and analgesia are major components of many interventional studies on laboratory animals. However, various studies have shown improper reporting or use of anesthetics/analgesics in research proposals and published articles. In many cases, it seems “anesthesia” and “analgesia” are used interchangeably, while they are referring to two different concepts. Not only this is an unethical practice, but also it may be one of the reasons for the proven suboptimal quality of many animal researches. This is a widespread problem among investigations on various species of animals. However, it could be imagined that it may be more prevalent for the most common species of laboratory animals, such as the laboratory mice. In this review, proper anesthetic/analgesic methods for routine procedures on laboratory mice are discussed. We considered the available literature and critically reviewed their anesthetic/analgesic methods. Detailed dosing and pharmacological information for the relevant drugs are provided and some of the drugs’ side effects are discussed. This paper provides the necessary data for an informed choice of anesthetic/analgesic methods in some routine procedures on laboratory mice.
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KEYWORD
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Anesthetic, Analgesic, Mouse, Pharmacology, Side effect, Preclinical
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