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KMID : 1204320230390010023
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Laboratory Animal Research
2023 Volume.39 No. 1 p.23 ~ p.23
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Chemosensitivity to doxorubicin in primary cells derived from tumor of FVB/N-Trp53tm1Hw1 with TALEN-mediated Trp53 mutant gene
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Yun Woo-Bin
Kim Ji-Eun
Jin You-Jeong
Roh Yu-Jeong
Song Hee-Jin
Seol A-Yun
Kim Tae-Ryeol
Min Kyeong-Seon
Park Eun-Seo
Park Gi-Ho
Kang Hyun-Gu
Choi Yeon-Shik
Hwang Dae-Youn
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Abstract
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Background : To evaluate the chemosensitivity to doxorubicin (DOX) in two primary cells derived from a tumor of FVB/N-Trp53tm1Hw1 knockout (KO) mice with TALEN-mediated Trp53 mutant gene, we evaluated the cell survivability, cell cycle distribution, apoptotic cell numbers and apoptotic protein expression in solid tumor cells and ascetic tumor cells treated with DOX.
Results : The primary tumor cells showed a significant (P?
Conclusions : To the best of our knowledge, these results are the first to successfully detect an alteration in chemosensitivity to DOX in solid tumor cells and ascetic tumor cells derived from tumor of FVB/N-Trp53tm1Hw1 mice TALEN-mediated Trp53 mutant gene.
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KEYWORD
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Chemosensitivity, Doxorubicin, Trp53, Solid tumor, Ascetic tumor, G2 arrest
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