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KMID : 1204320230390010029
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Laboratory Animal Research
2023 Volume.39 No. 1 p.29 ~ p.29
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Promising improvement in infected Wound Healing in Type two Diabetic rats by Combined effects of conditioned medium of human adipose-derived stem cells plus Photobiomodulation
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Kaysan Sohrabi
Houssein Ahmadi
Abdollah Amini
Behnaz Ahrabi
Atarodalsadat Mostafavinia
Hamidreza Omidi
Jung Young-Yun
Fatemeh Fadaei Fathabady
Mohammadjavad Fridoni
Maryam Rahmannia
Sufan Chien
Mohammad Bayat
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Abstract
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Background : We aimed to examine the accompanying and solo impacts of conditioned medium of human adipose-derived stem cells (h-ASC-COM) and photobiomodulation (PBM) on the maturation stage of an ischemic infected delayed-healing wound model (IIDHWM) of rats with type 2 diabetes (TIIDM).
Results : Outcomes of the wound closure ratio (WCR) results, tensiometrical microbiological, and stereological assessment followed almost identical patterns. While the outcomes of h-ASC-COM?+?PBM, PBM only, and h-ASC-COM only regimes were significantly better for all evaluated methods than those of group 1(all, p?
Conclusions : h-ASC-COM?+?PBM, PBM, and h-ASC-COM cures expressively accelerated the maturation stage in the wound healing process of IIDHWM with MRSA in TIIDM rats by diminishing the inflammatory reaction, and the microbial flora of MRSA; and increasing wound strength, WCR, number of fibroblasts, and new blood vessels. While the h-ASC-COM?+?PBM and PBM were more suitable than the effect of h-ASC-COM, the results of h-ASC-COM?+?PBM were superior to PBM only.
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KEYWORD
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Diabetes mellitus, Diabetic foot ulcers, Human adipose-derived stem cell, Conditioned medium, Photobiomodulation, Microbial flora, Stereology, Rat
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