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KMID : 1225120110030010023
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Vascular Neurology
2011 Volume.3 No. 1 p.23 ~ p.26
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Therapeutic Effects of Erythropoietin and Granulocyte Colony-Stimulating Factor in Stroke
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Yu Ji-Hye
Cho Sung-Rae
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Abstract
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Granulocyte colony-stimulating factor (G-CSF) was identified among a set of humoral factors on survival, proliferation, and differentiation of hematopoietic cells. Erythropoietin (EPO), produced mainly in the adult kidney, is a major growth regulator of the erythroid cell lineage. The EPO has the function of an oxygen-dependent regulation of red blood-cell mass, and it is used to treat various anemias including anemia related to chronic kidney disease and certain forms of cancer. In addition, both EPO and G-CSF have been shown to possess anti-apoptotic, angiogenic and neuroprotective properties and have also been regarded as therapeutic agents in acute stroke models. Moreover, the co-treatment of G-CSF and EPO synergistically enhances neural plasticity and angiogenesis in animal models of cerebral ischemia.
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KEYWORD
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Granulocyte colony-stimulating factor, Erythropoietin, Neural plasticity, Angiogenesis, Stroke
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