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KMID : 1225120120040010027
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Vascular Neurology
2012 Volume.4 No. 1 p.27 ~ p.30
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Metabolic Impairments of Brain in Patients with Probable Dementia of Lewy Bodies
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Yang Young-Soon
Kang Jin-Ho
Joo Jae-Jeong
Lee Sun-Hwa
Ha Sang-Won
Han Jung-Ho
Cho Eun-Kyoung
Kim Doo-Eung
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Abstract
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Objective: Lewy body disease is, after Alzheimer’s disease (AD), the second most common cause of senile degenerative dementia with progressive cognitive deterioration, fluctuation of cognitive and motoric functions and psychotic symptoms. It is characterized histologically by the occurrence of Lewy bodies in allocortical, neocortical and subcortical structures. The aim of this study was to measure the cortical glucose metabolism using 2-[18F]fluoro-2-deoxy-D-glucose position emission tomography (FDG PET).
Methods: Fourty three patients (11 M, 32 F, mean age 66.16 y) with clinically suspected dementia of Lewy bodies (DLB) were studied with FDG PET.
Results: We found diffuse glucose hypometabolism in the entire cortex including the occipital region seems to be a typical feature of DLB that is distinctive from dementia of AD.
Conclusions: The cortical hypometabolism containing of the occipital areas could be a result of diaschisis due to disruption of intracortical connections, which the limited occipital hypometabolism may be manifested not only in DLB.
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KEYWORD
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DLB, FDG-PET, AD
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