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KMID : 1225120180060010003
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Vascular Neurology
2018 Volume.6 No. 1 p.3 ~ p.7
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Vascular Hypothesis in AD
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Kwak Yong-Tae
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Abstract
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The cause of Alzheimer’s disease (AD) is still not clearly known. Encountering setback of traditional amyloid cascade hypothesis, the vascular hypothesis of AD emerged as an alternative to this hypothesis as pathophysiological cause of AD. This hypothesis considers cerebral vascular dysfunction as a primary trigger for pathogenic pathways of neuronal dysfunction. Dysfunction of the blood-brain barrier, decreased cerebral blood flow, and the various inflammatory context would promote aggregation of Aβ peptide in the brain, thus be responsible for subsequent neuronal damage. The idea that vascular dysfunctions are key promotor of neurodegeneration has provided new perspectives for therapeutic approaches that will add to the treatments for AD.
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KEYWORD
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Alzheimer’s disease, Amyloid cascade hypothesis, Vascular hypothesis, Aβ
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