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KMID : 1236020140420030249
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Microbiology and Biotechnology Letters
2014 Volume.42 No. 3 p.249 ~ p.257
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Anti-Oxidative and Anti-Obesity Effects of Amomum Cardamomum L. Extract
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Park Jung-Ae
Jin Kyong-Suk
Lee Ji-Young
Kwon Hyun-Ju
Kim Byung-Woo
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Abstract
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In this study, the anti-oxidative and anti-obesity activities of Amomum cardamomum L. methanol extract (ACME) were evaluated using DPPH radical scavenging activity assay, pancreatic lipase enzyme inhibition assay, and the cell culture model system. ACME exhibited DPPH radical scavenging activities dose-dependently, with IC50 of DPPH radical scavenging activities of ACME being 25.15 μg/ml. Furthermore, ACME effectively suppressed pancreatic lipase enzyme activity dose-dependently. ACME also significantly suppressed adipocyte differentiation, lipid accumulation, triglyceride (TG) contents, and triggered lipolysis activity on 3T3-L1 preadipocytes in a dose-dependent manner, without cytotoxicity. Their anti-obesity effect was modulated by the cytidine-cytidine-adenosine-adenosine-thymidine (CCAAT)/enhancer binding proteins α (C/EBPα), C/EBPβ and the peroxisome proliferator-activated receptor γ (PPARγ) gene and protein expressions. Taken together, these results provide an important new insight that A. cardamomum L. possesses anti-oxidative and anti-obesity activities such as pancreatic lipase inhibition, anti-adipogenic, and lipolysis effects. There is therefore potential for its use as a promising component in the field of nutraceuticals and the identification of the active compounds that confer the anti-oxidative and anti-obesity activities of ACME might be an appropriate next step.
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KEYWORD
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Amomum cardamomum L. methanol extract, anti-oxidative activity, anti-obesity activity, lipase inhibition activity, anti-adipogenic and lipolysis effects
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