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KMID : 1236020150430040343
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Microbiology and Biotechnology Letters
2015 Volume.43 No. 4 p.343 ~ p.349
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Decrease in the Particle Size of Paclitaxel by Increased Surface Area Fractional Precipitation Process Using Hydrophilic Polymer
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Lim Yong-Kyu
Kim Jin-Hyun
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Abstract
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In this study, we applied an increased surface area fractional precipitation with hydrophilic polymer for decreasing the particle size of the anticancer agent paclitaxel from plant cell cultures. The addition of polymer resulted in a considerable decrease in the size of the paclitaxel precipitate. Among the polymers (HPMC 2910, PVP-K90, PVA) used, PVP-K90 was the most effective for the inhibition of precipitate growth. When PVP-K90 (0.2%, w/v) was used, the paclitaxel particles were four to five times smaller, having less than a 20 μm radius, than those obtained in the absence of the polymer. In addition, the precipitate size was inversely correlated with the absolute value of zeta potential.
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KEYWORD
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Pacitaxel, Increased surface area fractional precipitation, Polymer, Particle size, Decrease
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