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KMID : 1239920070010020094
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Nutrition Research and Practice
2007 Volume.1 No. 2 p.94 ~ p.99
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Effect of mucilage from yam on activation of lymphocytic immune cells
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Jang Cheol-Min
Kweon Dae-Hyuk
Lee Jong-Hwa
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Abstract
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The immunostimulating activities of mucilage fraction from yam were investigated. The proliferation of BSA-primed lymph node cells was enhanced between 4.1- to 10.9-fold compare to control, when cultured with 1 to 25 μg/mL of yam-mucilage fraction. It showed strong immunopotentiatingactivity than ginseng extract and as remarkable as Bifidobacterium adolescentis M101-4 known as a positive immunostimulator. Mitogenicity to lymph node cells was fully induced by concanavalin A and lipopolysaccharide. The proliferation of splenocytes and Peyer’s patch cells was enhanced
between 5.0- to 14.1-fold and 2.4- to 6.4-fold, respectively, when cultured with 1 to 25 μg/mL of yam-mucilage fraction. It enhanced the production of cytokines such as tumor necrosis factor-α and IL-6 in the culture of RAW 264.7 macrophage cells. In the culture of lipopolysaccharide-stimulated RAW 264.7 cells, production of cytokines was as similar as compared to controls. In unstimulated RAW 264.7 cells, both tumor necrosis factor-α and IL-6 production were enhanced between 15.6- to 60.1-fold and 2.3- to 9.1-fold, respectively. Mucilage fraction from yam is expected to be a safe immunopotentiator to maintain the host immunity and develop a physiologically functional food.
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KEYWORD
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Yam-mucilage, immunostimulation, lymphocyte proliferation, cytokine, functional food
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