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KMID : 1239920070010040285
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Nutrition Research and Practice
2007 Volume.1 No. 4 p.285 ~ p.290
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Resveratrol blunts tumor necrosis factor-α-induced monocyte adhesion and transmigration
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Kim Dong-Shoo
Kwon Hyang-Mi
Choi Jung-Suk
Kang Sang-Wook
Ji Geun-Eog
Kang Young-Hee
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Abstract
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The leukocyte recruitment and transmigration across the endothelial barrier into the vessel wall are crucial steps in atherosclerosis. Leukocyte trafficking on the endothelium is elicited by induction of endothelial adhesion molecules, and its transmigration is mediated by degradation of basement membrane proteins through enzymatic activity of matrix metalloproteinases (MMP). The current study investigated whether resveratrol, a polyphenol present in grapes and red wine, was capable of inhibiting leukocyte adhesion to tumor necrosis factor (TNF)-α-activated endothelium. It was found
that resveratrol inhibited the TNF-α-activated endothelial expression of vascular cell adhesion molecule-1 in a dose-dependent manner. In addition, resveratrol hampered THP-1 monocyte adhesion to activated endothelial cells. This study further examined whether resveratrol interfered with transendothelial migration of leukocytes. The MMP-2 gelatinolytic activity of endothelial cells was enhanced by TNF-α, which was attenuated by an addition of ≥25 μM resveratrol. In addition, 25 μM resveratrol mitigated the MMP-9 activity of THP-1 cells, followed by a marked inhibition of transendothelial
migration. These results demonstrated that resveratrol suppressed monocyte adhesion and migration induced by TNF-α through modulating expression of adhesion molecules and gelatinolytic activity of MMP. These findings suggest that
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KEYWORD
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Resveratrol, TNF-α, VCAM-1, THP-1 monocyte, MMP
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