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KMID : 1239920120060040294
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Nutrition Research and Practice
2012 Volume.6 No. 4 p.294 ~ p.300
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Effect of resveratrol on the metastasis of 4T1 mouse breast cancer cells in vitro and in vivo
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Lee Hyun-Sook
Ha Ae-Wha
Kim Woo-Kyoung
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Abstract
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We investigated the effects of resveratrol on metastasis in in vitro and in vivo systems. 4T1 cells were cultured in the presence of various concentrations (0-30 μmol/L) of resveratrol. For experimental metastasis, BALB/c mice were injected intravenously with 4T1 cells in the tail vein, and were orally administered various concentrations (0, 100, or 200 mg/kg Body weight) of resveratrol for 21 days. After resveratrol treatment, cell adhesion, wound migration, invasion, and MMP-9 activity were significantly decreased in a dose-dependent manner in 4T1 cells (P < 0.05). The numbers of pulmonary nodules were significantly decreased in mice fed the resveratrol (P < 0.05). The plasma MMP-9 activity was decreased in response to treatment with resveratrol in mice (P < 0.05). We conclude that resveratrol inhibits cancer metastasis both in vitro and in vivo, and this inhibition is likely due to the decrease in MMP-9 activity caused by resveratrol.
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KEYWORD
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Resveratrol, metastasis, matrix metalloproteinase-9, 4T1 breast cancer cell, BALB/c mice
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