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KMID : 1239920140080020172
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Nutrition Research and Practice
2014 Volume.8 No. 2 p.172 ~ p.176
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Cordyceps militaris alleviates non-alcoholic fatty liver disease in ob/ob mice
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Choi Ha-Neul
Jang Yang-Hee
Kim Min-Joo
Seo Min-Jeong
Kang Byoung-Won
Jeong Yong-Kee
Kim Jung-In
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Abstract
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BACKGROUND/OBJECTIVES: Non-alcoholic fatty liver disease (NAFLD) is becoming an important public health problem as metabolic syndrome and type 2 diabetes have become epidemic. In this study we investigated the protective effect of Cordyceps militaris (C. militaris) against NAFLD in an obese mouse model.
MATERIALS/METHODS: Four-week-old male ob/ob mice were fed an AIN-93G diet or a diet containing 1% C. militaris water extract for 10 weeks after 1 week of adaptation. Serum glucose, insulin, free fatty acid (FFA), alanine transaminase (ALT), and proinflammatory cytokines were measured. Hepatic levels of lipids, glutathione (GSH), and lipid peroxide were determined.
RESULTS: Consumption of C. militaris significantly decreased serum glucose, as well as homeostasis model assessment for insulin resistance (HOMA-IR), in ob/ob mice. In addition to lowering serum FFA levels, C. militaris also significantly decreased hepatic total lipids and triglyceride contents. Serum ALT activities and tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) levels were reduced by C. militaris. Consumption of C. militaris increased hepatic GSH and reduced lipid peroxide levels.
CONCLUSIONS: These results indicate that C. militaris can exert protective effects against development of NAFLD, partly by reducing inflammatory cytokines and improving hepatic antioxidant status in ob/ob mice.
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KEYWORD
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Cordyceps militaris, non-alcoholic fatty liver disease (NAFLD), triglyceride, antioxidant, ob/ob mice
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